Based in Vienna, this season Louisa Muller premieres a new production of The Wreckers for Houston Grand Opera, revives her production of Amadigi di Gaula for Philharmonia Baroque, and stages Ernani at Lyric Opera of Chicago. Future engagements include new productions for Santa Fe Opera, Theater an der Wien, Garsington Opera, and Pinchgut Opera. Her acclaimed production of The Turn of the Screw for Garsington Opera won a 2020 Royal Philharmonic Society Award and was named by The Guardian as one of the Top 10 classical events of the year. She was a finalist for the 2020 International Opera Awards in the Best Newcomer category.

She has directed at the Metropolitan Opera, Los Angeles Opera, Grand Théâtre de Genève, Houston Grand Opera, New York Philharmonic, Edinburgh International Festival, Minnesota Opera, Santa Fe Opera, Wolf Trap Opera, Opera Colorado, Boston Baroque, the Juilliard School, and Opera Queensland.